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Adenocarcinoma of the anal canal is a rare form of a rare tumor. It remains less prevalent than both basaloid and keratinizing tumors of the anal canal. Within the category of anal adenocarcinomas, uniformity in histology, biology, or etiology is lacking. This makes subdivision of this rare entity by various parameters necessary. adenocarcinoma arising from an anal gland is extremely rare. Most anal canal cancers are squamous cell carcinoma, and adenocarcinoma is infrequently diagnosed. Diagnostic criteria and the standard treatment for adenocarcinoma of the anal canal have not been clearly defined, in part because of the rarity of this lesion. anal mucoepidermoid carcinoma (rare j gastroenterol 200136508) secondary involvement by rectal adenocarcinoma (more common than primary anal adenocarcinoma usually ck20 may require clinical correlation) squamous cell carcinoma (far more common at.). anal carcinoma and 80 of anal cancers are squamous cell carcinomas (sccs). Other tumour types include melanoma , lymphoma and adenocarcinoma. Adenocarcinoma of anal canal is an adenocarcinoma arising in the epithelium of the anal canal including the mucosal surface, the anal glands, and the lining of fistulous tracts. The risk factors for the development of anal adenocarcinoma include smoking, hiv infection, homosexuality, anal crohns disease, and chronic fistula-in-ano. There is an increased incidence of anal sac adenocarcinoma in older, spayed female dogs, but a sex predilection has not been confirmed (goldschmidt and shofer, 1992). The majority of cases involve dogs, but occasional cases have been reported in cats. Grossly, this is a subcutaneous mass, firmly fixed around the anal sac that arises from the glands in the wall of these sacs. anal cancer tumors that develop from mucosa that cannot be visualized entirely while gentle traction is placed on the buttocks perianal cancer tumors that arise within the skin at or distal to the squamous mucocutaneous junction, can be seen entirely with gentle traction on the buttocks and are within 5 cm of the anus.