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Squamous cell carcinoma of the anus is the most common anal cancer. It forms in the lining of the anus, which passes faeces from the large intestine. squamous cell carcinomas in the anal canal have grown beyond the surface and into the deeper layers of the lining (as opposed to carcinoma in situ which is only in the surface cells). Squamous cell cancers are the most common type of anal cancer. Squamous cells carcinomas make up around 90 out of 100 (90) of all anal cancers. This type of anal cancer starts in squamous cells which make up the lining of the anal canal and anal margin. Human papillomavirus (hpv) squamous cell carcinoma of the anus is strongly associated with human papillomavirus (hpv) infection which represents the causative agent in 80-85 of patients (usually from hpv16 or hpv18 subtypes in europe) as is its precursor lesion anal intraepithelial neoplasia (ain). resembles squamous cell carcinoma as seen elsewhere in body tumors often display multiple morphologic patterns, calling into question the utility of subdividing the entity may be keratinizing (usually below the dentate line) or nonkeratinizing (anywhere, although tumors above dentate line are usually nonkeratinizing). Squamous cell (epidermoid) carcinomas make up the majority of all primary cancers of the anus. Historically, a subset of tumors arising from the epithelial transitional zone were categorized as cloacogenic or basaloid tumors however, these tumors are now recognized as nonkeratinizing squamous cell cancers and are similarly associated with human papilloma virus. in squamous cell carcinoma in situ, the malignancy is confined to the skin surface and no invasion or metastasis is observed how is squamous cell carcinoma in situ of anus diagnosed? Some of the tests that may help in diagnosing squamous cell carcinoma in situ of anus include complete physical examination with detailed medical history evaluation. The incidence rate of anal squamous cell carcinoma (ascc) ranges from 1. 5 per 100,000 population in a lot of developed countries, which is an rare malignancy of the anal canal and perianal skin area. The annual incidence increases by about 2, especially in females 24.