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This case demonstrates that anal canal adenocarcinoma with distant metastases could be successfully treated with mfolfox6 bevacizumab therapy according to the guidelines for rectal carcinoma. However, as anal canal carcinoma has multiple histological subtypes, it is important to establish subtype-specific treatment strategies. avastin (bevacizumab) is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Avastin is used to treat a certain type of brain tumor, and certain types of cancers of the kidney, lung, colon, rectum, cervix, ovary, or fallopian tube. Avastin is also used to treat cancer of the membrane lining the internal organs in your abdomen. pembrolizumab in refractory metastatic anal cancer the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the u. Learn about avastin (bevacizumab) solution for iv infusion, including benefits, risks, possible side effects, patient support, and options for financial help. The clinical trials on this list are for anal cancer treatment. Ncis basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. Recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer (roc) avastin, in combination with paclitaxel, pegylated liposomal doxorubicin, or topotecan, is indicated for the treatment of patients with platinum-resistant recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer who received no more than 2 prior chemotherapy regimens. Following clinical and radiographic evaluation, this patient was judged to have a clinical stage t4n1mx distal rectal cancer. The patient enrolled in a phase ii clinical trial (nci protocol 5642) of neoadjuvant bevacizumab (a vegf-specific antibody), in combination with 5-fluorouracil (5-fu) and radiation therapy. Squamous cell carcinoma of the anal canal (scca) is a rare gastrointestinal malignancy with an increasing annual incidence globally. The majority of cases are linked to prior infection with the human papillomavirus (hpv). For patients with metastatic scca, no consensus standard treatment exists. Identification of relevant targeted agents as novel therapeutic approaches for metastatic scca has. 5 mgkg iv dose evaluated in first-line mcrc in combination with 5-fluorouracil (5-fu)leucovorin (lv)irinotecan (ifl). 10 mgkg iv dose evaluated in second-line, avastin-naive mcrc patients in combination with 5-fulvoxaliplatin (folfox4). 5 mgkg iv every 3 weeks doses evaluated, in combination with fluoropyrimidine and either irinotecan- or. Backgroundvascular endothelial growth factor (vegf) promotes angiogenesis, a mediator of disease progression in cervical cancer.