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I started having vaginal itching around my vulva, in between my labia and around my anus for about 5 days now. I tried 2 of 3 days of an otc yeast medicine and had my doctor call in 1 pill of diflucan all with no relief. An anal yeast infection is often characterized by persistent and intense anal itching. Your doctor will perform a quick physical exam to determine the cause, such as hemorrhoids or a yeast infection. Is fluconazole helpful for anal itching? Can fluconazole cause anal itching? Fluconazole is mentioned in 12 posts about anal itching. An autoimmune skin disorder can make your bodys immune system attack its own cells. Medicines anal itching may be a side effect of some medicines used to treat gout, arthritis, or infections. Creams, ointments, or medicines used to treat other anal problems may also cause anal itching. it started out as an anal itch, let it go for 2 months then it spread to the front used all kinds of yeast creams, diflucan days at a time, just went to gyno but negative for everything, but she told me to stay on diflucan for 2 weeks just in case, well if i skip a day of diflucan i already feel an itch, but i never had discharge? When i have painful bowel movements thats when anas gets. To randrews8902 from bestpup sounds to me like the monistat cream and the diflucan have done their job and stopped the infectionitching. I would apply a little vaseline to help in the aid of the blisters. Candida anal itch can often be caused by overgrowth of candida albicans. This fungus lives naturally in the digestive tract, colon and on the skin. Sometimes, the internal candida can spur the overproduction of fungus on the skin, including in the area of the anus.