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Nitroglycerin rectal ointment is used to relieve moderate to severe pain caused by chronic anal fissures. An anal fissure is a tear in the skin around the opening for bowel movements, also known as the anus or rectal area. Nitroglycerin belongs to the group of medicines called nitrates. User reviews for nitroglycerin to treat anal fissure and fistula. Nitroglycerin rectal is used to treat moderate to severe pain caused by chronic anal fissures (tears in the skin lining your rectum). Indicated for treatment of moderate-to-severe pain associated with chronic anal fissures consider use if conservative treatment for acute symptoms of anal fissure fails cover finger with plastic-wrap, disposable surgical glove or a finger cot and measure 1-inch (375 mg of ointment equivalent to 1.). nitroglycerin is usually the first medicine used to treat a chronic anal fissure. Many studies have shown that it works better than conservative treatment (eating more fiber and taking sitz baths). Headaches are the main side effect of nitroglycerin ointment. Nitroglycerin ointment treats moderate to severe pain caused in the lining of the anus, mostly anal fissures. The ointment works by relaxing the muscles around the blood vessels which reduces pressure inside the anus and relieves pain and is considered a common fissure treatment in india. Nitroglycerin is in the nitrate family and works to dilate blood vessels, increasing blood flow to the anal fissure. It also reduces pressure in the internal anal sphincter, which decreases pain and further facilitates healing. Nitroglycerin was effective in 9 of 16 acute fissures (56), and 7 of 17 chronic fissures (41). Even when effective, 75 of patients reported an adverse reaction. Conclusions topical nitroglycerin was only effective in approximately one-half of patients with an anal fissure.